Journal article

Vascular Endothelial Growth Factor-d Modulates Caliber and Function of Initial Lymphatics in the Dermis

Sophie Paquet-Fifield, Sidney M Levy, Teruhiko Sato, Ramin Shayan, Tara Karnezis, Natalia Davydova, Cameron J Nowell, Sally Roufail, Gerry Zhi-Ming Ma, You-Fang Zhang, Steven A Stacker, Marc G Achen



The lymphatic vasculature is important for skin biology as it maintains dermal fluid homeostasis. However, the molecular determinants of the form and function of the lymphatic vasculature in skin are poorly understood. Here, we explore the role of vascular endothelial growth factor-d (Vegf-d), a lymphangiogenic glycoprotein, in determining the form and function of the dermal lymphatic network, using Vegf-d-deficient mice. Initial lymphatic vessels in adult Vegf-d-deficient mice were significantly smaller than wild-type but collecting lymphatics were unaltered. The uptake/transport of dextran in initial lymphatics of Vegf-d-deficient mice was far less efficient, indicating compromised functio..

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Funding Acknowledgements

This work was supported by a Program Grant and Research Fellowships (to SA Stacker and MG Achen) from the National Health and Medical Research Council of Australia (NHMRC), and by funds from the Operational Infrastructure Support Program provided by the Victorian Government, Australia. R Shayan is supported by the Raelene Boyle Sporting Chance Foundation and the Royal Australasian College of Surgeons (RACS) Foundation Scholarship, and the RACS Surgeon Scientist Program. S Levy is supported by a NHMRC Postgraduate Scholarship, a RACS Eric Bishop Scholarship, a RACS Foundation for Surgery Catherine Marie Enright Scholarship, and a National Breast Cancer Foundation Doctoral Scholarship.