Journal article

Nudeoprotein of influenza A virus is a major target of immunodominant CD8( ) T-cell responses

Emma Grant, Chao Wu, Kok-Fei Chan, Sidonia Eckle, Mandvi Bharadwaj, Quan Ming Zou, Katherine Kedzierska, Weisan Chen

IMMUNOLOGY AND CELL BIOLOGY | WILEY | Published : 2013

Abstract

Influenza A virus causes annual epidemics and sporadic pandemics, resulting in significant morbidity and mortality worldwide. Vaccines are currently available; however, they induce a non-strain-cross protective humoral immune response directed against the rapidly mutating surface glycoproteins, and thus need to be updated annually. As T cells are directed against more conserved internal influenza proteins, a T-cell-based vaccine has the potential to induce long-lasting and cross-strain protective CD8(+) T-cell immunity, and in that way minimize the severity of influenza infection. However, to rationally design such vaccines, we need to identify immunogenic T-cell regions within the most anti..

View full abstract