Nudeoprotein of influenza A virus is a major target of immunodominant CD8( ) T-cell responses
Emma Grant, Chao Wu, Kok-Fei Chan, Sidonia Eckle, Mandvi Bharadwaj, Quan Ming Zou, Katherine Kedzierska, Weisan Chen
IMMUNOLOGY AND CELL BIOLOGY | WILEY | Published : 2013
Influenza A virus causes annual epidemics and sporadic pandemics, resulting in significant morbidity and mortality worldwide. Vaccines are currently available; however, they induce a non-strain-cross protective humoral immune response directed against the rapidly mutating surface glycoproteins, and thus need to be updated annually. As T cells are directed against more conserved internal influenza proteins, a T-cell-based vaccine has the potential to induce long-lasting and cross-strain protective CD8(+) T-cell immunity, and in that way minimize the severity of influenza infection. However, to rationally design such vaccines, we need to identify immunogenic T-cell regions within the most anti..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
This work was supported by Australian National Health and Medical Research Council (NHMRC) Project Grant to KK (AI1008854), an NHMRC Program Grant (APP567122) to WC. EJG was a recipient of the May Stewart Bursary, KK is an NHMRC CDF2 Fellow and WC is an NHMRC SRF Fellow.