Journal article

Neurocognitive predictors of transition to psychosis: medium- to long-term findings from a sample at ultra-high risk for psychosis

A Lin, AR Yung, B Nelson, WJ Brewer, R Riley, M Simmons, C Pantelis, SJ Wood



BACKGROUND: Individuals at ultra-high risk (UHR) for psychosis show reduced neurocognitive performance across domains but it is unclear which reductions are associated with transition to frank psychosis. The aim of this study was to investigate differences in baseline neurocognitive performance between UHR participants with (UHR-P) and without transition to psychosis (UHR-NP) and a healthy control (HC) group and examine neurocognitive predictors of transition over the medium to long term. METHOD: A sample of 325 UHR participants recruited consecutively from the Personal Assessment and Crisis Evaluation (PACE) Clinic in Melbourne and 66 HCs completed a neurocognitive assessment at baseline. T..

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Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

We thank K. Wardenaar for his valuable comments on this manuscript and A. Calvo for her assistance with data entry. This work was supported by National Health and Medical Research Council (NHMRC) Programme Grants (nos 350241 and 566529) and the Colonial Foundation. S.J.W. and W.J.B. were supported by NHMRC Career Development Awards. B.N. was supported by a Ronald Phillip Griffith Fellowship and a National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award. C.P. and A.R.Y. are the recipients of NHMRC Senior Principal and Senior Research Fellowships respectively. No funding source played any role in the collection, analysis, interpretation or publication of data.