Journal article

Nfil3 Is a Glucocorticoid-Regulated Gene Required for Glucocorticoid-Induced Apoptosis in Male Murine T Cells

Kirstyn T Carey, Kheng H Tan, Judy Ng, Douglas R Liddicoat, Dale I Godfrey, Timothy J Cole

ENDOCRINOLOGY | OXFORD UNIV PRESS INC | Published : 2013

Abstract

Glucocorticoids (GCs) have essential roles in the regulation of development, integrated metabolism, and immune and neurological responses, and act primarily via the glucocorticoid receptor (GR). In most cells, GC treatment results in down-regulation of GR mRNA and protein levels via negative feedback mechanisms. However, in GC-treated thymocytes, GR protein levels are maintained at a high level, increasing sensitivity of thymocytes to GCs, resulting in apoptosis termed glucocorticoid-induced cell death (GICD). CD4(+)CD8(+) double-positive thymocytes and thymic natural killer T cells in particular are highly sensitive to GICD. Although GICD is exploited via the use of synthetic GC analogues i..

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University of Melbourne Researchers

Grants

Awarded by National Health & Medical Research Council of Australia


Awarded by National Health & Medical Research Council


Funding Acknowledgements

This work was supported by Program Grant 384100 and Project Grant 350302 from the National Health & Medical Research Council of Australia; and National Health & Medical Research Council Senior Principal Research Fellowship 1020770 (to D. I. G.).