Journal article

Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua

Tu'uhevaha J Kaitu'u-Lino, Louie Ye, Laura Tuohey, Evdokia Dimitriadis, Judith Bulmer, Peter Rogers, Ellen Menkhorst, Michelle Van Sinderen, Jane E Girling, Natalie Hannan, Stephen Tong



STUDY QUESTION: What is the nature of cellular Corin expression in human gestational tissues? SUMMARY ANSWER: CORIN is expressed in non-pregnant late secretory phase endometrium, first trimester human implantation sites and is up-regulated with decidualization ex vivo. WHAT IS KNOWN ALREADY: Adequate trophoblast invasion and spiral artery remodeling/transformation is critical for successful implantation. CORIN, best known for its role in activating atrial natruietic peptide (ANP) to regulate blood pressure, has recently been proposed to be centrally involved in trophoblast invasion and spiral artery remodeling. It is postulated that ANP, activated by CORIN, promotes trophoblast invasion and ..

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Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This study was supported by The National Health and Medical Research Council of Australia (Salary support #490970, #490995). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.