Journal article
Lung stem cells: Do they exist?
Ivan Bertoncello, Jonathan L McQualter
RESPIROLOGY | WILEY | Published : 2013
DOI: 10.1111/resp.12073
Abstract
Recognition of the potential of stem cell-based therapies for alleviating intractable lung diseases has provided the impetus for research aimed at identifying regenerative cells in the adult lung, understanding how they are organized and regulated, and how they could be harnessed in lung regenerative medicine. In this review, we describe the attributes of adult stem and progenitor cells in adult organs and how they are regulated by the permissive or restrictive microenvironment in which they reside. We describe the power and limitations of experimental models, cell separative strategies and functional assays used to model the organization and regulation of adult airway and alveolar stem cell..
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Awarded by Australian National Health and Medical Research Council
Funding Acknowledgements
The authors are supported by grants from the Australian National Health and Medical Research Council (Grant 1009374) and the Victorian Cancer Agency.