Journal article

Mitochondrial Genome of the Eyeworm, Thelazia callipaeda (Nematoda: Spirurida), as the First Representative from the Family Thelaziidae

Guo-Hua Liu, Robin B Gasser, Domenico Otranto, Min-Jun Xu, Ji-Long Shen, Namitha Mohandas, Dong-Hui Zhou, Xing-Quan Zhu

PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2013


Human thelaziosis is an underestimated parasitic disease caused by Thelazia species (Spirurida: Thelaziidae). The oriental eyeworm, Thelazia callipaeda, infects a range of mammalian definitive hosts, including canids, felids and humans. Although this zoonotic parasite is of socio-economic significance in Asian countries, its genetics, epidemiology and biology are poorly understood. Mitochondrial (mt) DNA is known to provide useful genetic markers to underpin fundamental investigations, but no mt genome had been characterized for any members of the family Thelaziidae. In the present study, we sequenced and characterized the mt genome of T. callipaeda. This AT-rich (74.6%) mt genome (13,668 bp..

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Awarded by National S & T Major Program

Funding Acknowledgements

This work was supported in part by the National S & T Major Program (Grant No. 2012ZX10004220) and the Program for Outstanding Scientists in Agricultural Research. The present study was also supported by the Australian Research Council (RBG). Current research in the Gasser Lab is funded mainly by the Australian Research Council (ARC), the National Health and Medical Research Council (NHMRC) and Melbourne Water Corporation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.