Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity
Diana P Prata, Richard A Kanaan, Gareth J Barker, Sukhwinder Shergill, James Woolley, Lyudmila Georgieva, Marco M Picchioni, Eugenia Kravariti, Muriel Walshe, Matt Allin, Timothea Toulopoulou, Elvira Bramon, Colm McDonald, Vincent Giampietro, Robin M Murray, Michael Brammer, Michael O'Donovan, Philip McGuire
HUMAN BRAIN MAPPING | WILEY | Published : 2013
The oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes, the brain cells responsible for axonal myelination. Although it has been associated with psychiatric and neurological disorders, the impact of this gene on white matter integrity has never been investigated in humans. Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects. We found that the risk allele (A) was associated with reduced white matter integrity in the corona radiata bilaterally. This is consiste..View full abstract
Awarded by FCT foundation (Fundacaopara a Ciencia e Tecnologia, Portugal)
Awarded by Medical Research Council
Awarded by National Institute for Health Research
Contract grant sponsor: FCT foundation (Fundacaopara a Ciencia e Tecnologia, Portugal); Contract grant number: PAG9097; Contract grant sponsor: Wellcome Trust Training Fellowship.