SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition
Nadia J Kershaw, James M Murphy, Nicholas PD Liau, Leila N Varghese, Artem Laktyushin, Eden L Whitlock, Isabelle S Lucet, Nicos A Nicola, Jeffrey J Babon
Nature Structural and Molecular Biology | NATURE PUBLISHING GROUP | Published : 2013
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by US National Institutes of Health
Awarded by NHMRC Independent Research Institutes Infrastructure Support Scheme
Awarded by NATIONAL CANCER INSTITUTE
We thank P. Colman, P. Czabotar and M. Lawrence for advice and I. Segel for helpful discussions. This work was supported in part by the National Health and Medical Research Council of Australia (NHMRC), program grants 461219 and 1016647 (N.A.N.) and project grant 1011804 (J.J.B.), the US National Institutes of Health CA22556 (N.A.N.), the Victorian State Government Operational Infrastructure Support grant and the NHMRC Independent Research Institutes Infrastructure Support Scheme (361646). N.A.N. acknowledges fellowship support from the NHMRC, J.M.M. and J.J.B. from the Australian Research Council and L.N.V. from the Leukaemia Foundation of Australia and the Australian Stem Cell Centre. We thank the scientists at the MX and SAXS/WAXS beamlines at the Australian Synchrotron. Crystallization trials were performed at CSIRO collaborative crystallization centre (C3).