Journal article
The transcription factor T-bet is essential for the development of NKp46 innate lymphocytes via the Notch pathway
LC Rankin, JR Groom, M Chopin, MJ Herold, JA Walker, LA Mielke, ANJ McKenzie, S Carotta, SL Nutt, GT Belz
Nature Immunology | NATURE PUBLISHING GROUP | Published : 2013
DOI: 10.1038/ni.2545
Abstract
NKp46+ innate lymphoid cells (ILCs) serve important roles in regulating the intestinal microbiota and defense against pathogens. Whether NKp46+ ILCs arise directly from lymphoid tissue-inducer (LTi) cells or represent a separate lineage remains controversial. We reporTHere that the transcription factor T-bet (encoded by Tbx21) was essential for the development of NKp46+ ILCs but not of LTi cells or nuocytes. Deficiency in interleukin 22 (IL-22)-producing NKp46+ ILCs resulted in greater susceptibility of Tbx21-/- mice to intestinal infection. Haploinsufficient T-bet expression resulted in lower expression of the signaling molecule Notch, and Notch signaling was necessary for the transition of..
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Awarded by Howard Hughes Medical Institute
Funding Acknowledgements
We thank R. Robins-Browne, M. Camilleri, R. Cole, J. Cruickshank and the staff of the animal and flow cytometry facilities of the Walter and Eliza Hall Institute and Medical Research Council Laboratory of Molecular Biology for technical assistance. Supported by the National Health and Medical Research Council of Australia (G.T.B., S.L.N., S.C., L.R. and J.R.G.), the Sylvia and Charles Viertel Foundation (G.T.B.), the Howard Hughes Medical Institute (G.T.B.), the Australian Research Council (S.L.N.), the Leukaemia Foundation (M.J.H.), the American Asthma Foundation (J.A.W.), the Medical Research Council, the American Asthma Foundation (A.N.J.M.) and Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institutes Infrastructure Support Scheme.