Journal article

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

Akshay A D'Cruz, Jeffrey J Babon, Raymond S Norton, Nicos A Nicola, Sandra E Nicholson

PROTEIN SCIENCE | WILEY | Published : 2013

Abstract

The SPRY domain is a protein interaction module found in 77 murine and ~100 human proteins, and is implicated in important biological pathways, including those that regulate innate and adaptive immunity. The current definition of the SPRY domain is based on a sequence repeat discovered in the splA kinase and ryanodine receptors. The greater SPRY family is divided into the B30.2 (which contains a PRY extension at the N-terminus) and "SPRY-only" sub-families. In this brief review, we examine the current structural and biochemical literature on SPRY/B30.2 domain involvement in key immune processes and highlight a PRY-like 60 amino acid region in the N-terminus of "SPRY-only" proteins. Phylogene..

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Grants

Awarded by National Health and Medical Research Council (NHMRC), Australia


Awarded by NHMRC IRIISS


Awarded by Australian Research Council


Funding Acknowledgements

Grant sponsor: National Health and Medical Research Council (NHMRC), Australia; Grant numbers: 461219, 637348; NHMRC IRIISS; Grant number: 361646; NHMRC Fellowships to R.S.N, N.A.N, S.E.N; Grant sponsor: Australian Research Council; Future Fellowship FT110100169 to J.J.B; Grant Sponsor: Australian Government; Postgraduate Award to A. A. D.; Grant sponsor: Victorian State Government; Operational Infrastructure Scheme grant.