Journal article

A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis

Thomas R Hawn, Sarah J Dunstan, Guy E Thwaites, Cameron P Simmons, Nguyen Thuong Thuong, Thi Ngoc Lan Nguyen, Thi Quy Hoang, Thi Hong Chau Tran, Nguyen T Hieu, Stephanie Rodrigues, Marta Janer, Lue Ping Zhao, Tran Tinh Hien, Jeremy J Farrar, Alan Aderem

JOURNAL OF INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2006

Abstract

BACKGROUND: Although meningitis is the most severe form of infection caused by Mycobacterium tuberculosis, the immunopathogenesis of this disease is poorly understood. We tested the hypothesis that polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor protein that mediates signals from Toll-like receptors activated by mycobacteria, are associated with susceptibility to tuberculosis (TB). METHODS: We used a case-population study design in Vietnam with cord-blood control samples (n = 392) and case patients (n = 358) who had either pulmonary (n = 183) or meningeal (n = 175) TB. RESULTS: The TIRAP single-nucleotide polymorphism (SNP) C558T was associa..

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University of Melbourne Researchers