Journal article
Haemodynamic influences on kidney oxygenation: Clinical implications of integrative physiology
RG Evans, C Ince, JA Joles, DW Smith, CN May, PM O'Connor, BS Gardiner
Clinical and Experimental Pharmacology and Physiology | WILEY | Published : 2013
Abstract
Renal blood flow, local tissue perfusion and blood oxygen content are the major determinants of oxygen delivery to kidney tissue. Arterial pressure and segmental vascular resistance influence kidney oxygen consumption through effects on glomerular filtration rate and sodium reabsorption. Diffusive shunting of oxygen from arteries to veins in the cortex and from descending to ascending vasa recta in the medulla limits oxygen delivery to renal tissue. Oxygen shunting depends on the vascular network, renal haemodynamics and kidney oxygen consumption. Consequently, the impact of changes in renal haemodynamics on tissue oxygenation cannot necessarily be predicted intuitively and, instead, require..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia
Awarded by American Heart Association
Awarded by Dutch Kidney Foundation
Awarded by American Heart Association (AHA)
Funding Acknowledgements
The authors' work reported herein has been supported by grants from the National Health and Medical Research Council of Australia (143603, 143785, 384101, 606601 and 1024575 to RGE), the American Heart Association (0625793Z to PMO) and the Dutch Kidney Foundation (C08.2263 to JAJ; C092.2290 to CI). The authors thank Dr Anita Layton (Department of Mathematics, Duke University, Durham, NC, USA) for her personal communication regarding the estimate of the quantity of oxygen shunted in the medullary circulation.