Journal article
A single mild fluid percussion injury induces short-term behavioral and neuropathological changes in the Long-Evans rat: Support for an animal model of concussion
SR Shultz, DF MacFabe, KA Foley, R Taylor, DP Cain
Behavioural Brain Research | Published : 2011
Abstract
Brain concussion is a serious public health concern and is associated with short-term cognitive impairments and behavioral disturbances that typically occur in the absence of significant brain damage. The current study addresses the need to better understand the effects of a mild lateral fluid percussion injury on rat behavior and neuropathology in an animal model of concussion. Male Long-Evans rats received either a single mild fluid percussion injury or a sham-injury, and either a short (24. h) or long (4 weeks) post-injury recovery period. After recovery, rats underwent a detailed behavioral analysis consisting of tests for rodent anxiety, cognition, social behavior, sensorimotor function..
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Funding Acknowledgements
This research was supported by a grant from the Natural Science and Engineering Research Council (NSERC) to Dr. Donald P. Cain, a scholarship from NSERC to Sandy R. Shultz, and contributions from GoodLife Childrens's Foundation and Round for a Reason Charities to Derrick F. MacFabe. We thank Dr. Richard Sutton and Dr. David Hovda from the UCLA Brain Injury Research Center for their help in LFP training. Additional thanks go to Lisa Tichenoff and Francis Boon for their assistance in the research project.