Journal article

HETEROLOGOUS PROTECTION AGAINST ROTAVIRUS-INDUCED DISEASE IN GNOTOBIOTIC PIGLETS

RF BISHOP, SR TZIPORI, BS COULSON, LE UNICOMB, MJ ALBERT, GL BARNES

JOURNAL OF CLINICAL MICROBIOLOGY | AMER SOC MICROBIOLOGY | Published : 1986

Abstract

Administration per os of 2 X 10(6) fluorescent cell-forming units of a human serotype 3 rotavirus (RV-3) protected all of nine gnotobiotic piglets against severe diarrheal disease when they were challenged 10 to 14 days later with 8 X 10(3) fluorescent cell-forming units of virulent wild-type porcine rotavirus (AT/76). The porcine virus was similar antigenically to porcine prototype strain OSU, previously described as antigenically distinct from all four recognized human serotypes. Administration of RV-3 was associated with the development of serum-neutralizing antibody to both RV-3 and AT/76 in piglets that excreted RV-3. Neutralizing antibody levels to RV-3 and AT/76 increased rapidly post..

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University of Melbourne Researchers