Journal article

ROLE OF COPROANTIBODY IN CLINICAL-PROTECTION OF CHILDREN DURING REINFECTION WITH ROTAVIRUS

BS COULSON, K GRIMWOOD, IL HUDSON, GL BARNES, RF BISHOP

Journal of Clinical Microbiology | AMER SOC MICROBIOLOGY | Published : 1992

Abstract

Rotavirus is the major cause of severe, dehydrating infantile gastroenteritis. Infection is limited to the gut, but the relative roles of serum and secretory copro-immunoglobulin A (IgA) in protection are unclear. Specific copro-IgA is predictive of duodenal antirotaviral IgA and correlates with virus-neutralizing coproantibody. Copro-IgA conversion is a more sensitive marker of rotavirus reinfection than seroconversion. We measured rotavirus reinfections by copro-IgA conversion prospectively in 35 children recruited at a time of severe rotavirus illness. The children were followed up longitudinally for 14 to 31 months to determine whether high coproantibody levels correlated with clinical p..

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University of Melbourne Researchers