Journal article

Recurrence of extensive injection site reactions following DTPa or dTpa vaccine in children 4-6 years old

Patrick Quinn, Michael Gold, Jenny Royle, Jim Buttery, Peter Richmond, Peter McIntyre, Nick Wood, Su-san Lee, Helen Marshall

VACCINE | ELSEVIER SCI LTD | Published : 2011


OBJECTIVES: The aim of this study was to compare the immunogenicity and reactogenicity of a lower dose diphtheria, tetanus and pertussis vaccine (dTpa) with the recommended vaccine (DTPa) given as a fifth dose to 4-6-year old children who previously experienced an extensive injection site reaction (ISR). MATERIAL AND METHODS: Children aged 4-6 years who had experienced an extensive ISR following a 4th dose of DTPa were recruited and randomly assigned to receive either the recommended DTPa or the lower dose dTpa vaccine. Parents recorded local reactions and systemic events for 15 days following vaccination. Immunogenicity was assessed pre and post vaccination by ELISA for diphtheria (D), teta..

View full abstract