Journal article
Rapid and Sensitive Detection of Rotavirus Molecular Signatures Using Surface Enhanced Raman Spectroscopy
Jeremy D Driskell, Yu Zhu, Carl D Kirkwood, Yiping Zhao, Richard A Dluhy, Ralph A Tripp
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2010
Abstract
Human enteric virus infections range from gastroenteritis to life threatening diseases such as myocarditis and aseptic meningitis. Rotavirus is one of the most common enteric agents and mortality associated with infection can be very significant in developing countries. Most enteric viruses produce diseases that are not distinct from other pathogens, and current diagnostics is limited in breadth and sensitivity required to advance virus detection schemes for disease intervention strategies. A spectroscopic assay based on surface enhanced Raman scattering (SERS) has been developed for rapid and sensitive detection of rotavirus. The SERS method relies on the fabrication of silver nanorod array..
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Awarded by U.S. Army Research Laboratory
Funding Acknowledgements
This work was supported by the U.S. Army Research Laboratory (http://www.arl.army.mil/www/default.htm) contract number W911NF-07-0065 and the Georgia Research Alliance (http://www.gra.org/Default.aspx). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.