Amino Acid Balance with Extended Daily Diafiltration in Acute Kidney Injury
Horng Ruey Chua, Ian Baldwin, Nigel Fealy, Toshio Naka, Rinaldo Bellomo
BLOOD PURIFICATION | KARGER | Published : 2012
BACKGROUND: The impact of hybrid dialysis therapies on amino acid (AA) balance in critically ill patients with acute kidney injury is unknown. METHODS: We examined prospectively the AA balance with extended daily diafiltration (EDDF). RESULTS: We studied 7 patients. AA clearances with EDDF ranged from 21.6 ml/min (tryptophan) to 66.9 ml/min (taurine). AA loss was 4.2 (IQR 1.4-12.3) g/day and 4.5% of daily protein intake for patients on enteral nutrition (EN). Percentage AA loss per hour on EDDF was highest for glutamine (32.1%) and lowest for glutamic acid (0.8%). Blood AA levels correlated with corresponding EDDF losses. Median total nitrogen appearance was 25.0 (IQR 20.6-29.3) g/day for pa..View full abstract
Dr. Horng Ruey Chua was a recipient of the Singapore Health Manpower Development Programme (HMDP) award in 2010, which was co-funded by the Ministry of Health (MOH) Singapore, and National University Health System (NUHS) Singapore. The funds were utilized for his clinical and research training in Austin Health, Melbourne, Vic., Australia.