Journal article
Variability in vitamin D assays impairs clinical assessment of vitamin D status
JKC Lai, RM Lucas, E Banks, AL Ponsonby
Internal Medicine Journal | Published : 2012
Abstract
Background: Measuring serum 25(OH)D concentration is common in clinical practice despite the questionable reliability of assays. Aims: The aim of the present study was to examine agreement in 25(OH)D concentrations measured by different assays and laboratories, and consider related clinical implications. Methods: Serum samples from 813 participants in the Australian Multicentre Study of Environment and Immune Function (the Ausimmune Study) were assayed for 25(OH)D concentration. Duplicate samples from subsets of subjects were sent to different laboratories, two using DiaSorin Liaison (Laboratory A and B) and one using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS - selected here a..
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Funding Acknowledgements
Funding: Funding for the Ausimmune Study was provided by the National Multiple Sclerosis Society of the United States of America, the National Health and Medical Research Council of Australia and Multiple Sclerosis Research Australia. A/Professor Lucas is supported by a Multiple Sclerosis Research Australia Fellowship and the Royal Australasian College of Physicians Cottrell Fellowship. Professor Banks is supported by an Australian National Health and Medical Research Council Senior Research Fellowship.