Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images
Jeremy FP Ullmann, Marianne D Keller, Charles Watson, Andrew L Janke, Nyoman D Kurniawan, Zhengyi Yang, Kay Richards, George Paxinos, Gary F Egan, Steven Petrou, Perry Bartlett, Graham J Galloway, David C Reutens
NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2012
The C57BL mouse is the centerpiece of efforts to use gene-targeting technology to understand cerebellar pathology, thus creating a need for a detailed magnetic resonance imaging (MRI) atlas of the cerebellum of this strain. In this study we present a methodology for systematic delineation of the vermal and hemispheric lobules of the C57BL/6J mouse cerebellum in magnetic resonance images. We have successfully delineated 38 cerebellar and cerebellar-related structures. The higher signal-to-noise ratio achieved by group averaging facilitated the identification of anatomical structures. In addition, we have calculated average region volumes and created probabilistic maps for each structure. The ..View full abstract
We would like to thank the National Imaging Facility (NIF) and the Queensland NMR Network (QNN) for access to the 16.4 T scanner and technical support. This project was funded by the National Health and Medical Research Council (NHMRC) of Australia.