Journal article
The human testis-determining factor SRY localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism
DP Czech, J Lee, H Sim, CL Parish, E Vilain, VR Harley
Journal of Neurochemistry | WILEY | Published : 2012
Abstract
The male gender is determined by the sex-determining region on the Y chromosome (SRY) transcription factor. The unexpected action of SRY in the control of voluntary movement in male rodents suggests a role in the regulation of dopamine transmission and dopamine-related disorders with gender bias, such as Parkinson's disease. We investigated SRY expression in the human brain and function in vitro. SRY immunoreactivity was detected in the human male, but not female substantia nigra pars compacta, within a sub-population of tyrosine hydroxylase (TH) positive neurons. SRY protein also co-localized with TH positive neurons in the ventral tegmental area, and with GAD-positive neurons in the substa..
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Awarded by National Institute of Mental Health
Funding Acknowledgements
Tissues were received from the Victorian Brain Bank Network (C. McLean), supported by the Mental Health Research Institute, Alfred Hospital, Victorian Forensic Institute of Medicine, The University of Melbourne and funded by Australia's National Health & Medical Research Council (NHMRC), Helen Macpherson Smith Trust, Parkinson's Victoria and Perpetual Philanthropic Services. This study was supported by the U.S. National Institute of Health (5RO1MH075046) and Australian NHMRC grants 334314 and 546517 to VRH, 1029401 to JL and by the Victorian Government's Operational Infrastructure Support Program. DPC is the recipient of an Australian Postgraduate Award. CLP is supported by a NHMRC (Australia) career development fellowship. PHI Data Audit #11-10. There are no conflicts of interest to report.