Journal article

Sulcogyral patterns and morphological abnormalities of the orbitofrontal cortex in psychosis

Cali F Bartholomeusz, Sarah L Whittle, Alice Montague, Brendan Ansell, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis, Stephen J Wood

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2013

Abstract

Three types of OFC sulcogyral patterns have been identified in the general population. The distribution of these three types has been found altered in individuals at genetic risk of psychosis, first episode psychosis (FEP) and chronic schizophrenia. The aim of this study was to replicate and extend previous research by additionally investigating: intermediate and posterior orbital sulci, cortical thickness, and degree of gyrification/folding of the OFC, in a large sample of FEP patients and healthy controls. OFC pattern type was classified based on a method previously devised, using T1-weighted magnetic resonance images. Cortical thickness and local gyrification indices were calculated using..

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Grants

Awarded by two National Health and Medical Research Council (NHMRC) of Australia


Awarded by NHMRC


Funding Acknowledgements

This work was supported by the Colonial Foundation and two National Health and Medical Research Council (NHMRC) of Australia Program Grants (566529, 350241). Dr C.F. Bartholomeusz and Dr S. L. Whittle are each supported by NHMRC fellowships (567042 and 1007716, respectively). Christos Pantelis was supported by a NHMRC Senior Principal Research Fellowship (ID: 628386), and a Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award.