Journal article

The search for an HIV cure: tackling latent infection

Stephen J Kent, Jeanette C Reece, Janka Petravic, Alexey Martyushev, Marit Kramski, Robert De Rose, David A Cooper, Anthony D Kelleher, Sean Emery, Paul U Cameron, Sharon R Lewin, Miles P Davenport



Strategies to eliminate infectious HIV that persists despite present treatments and with the potential to cure HIV infection are of great interest. One patient seems to have been cured of HIV infection after receiving a bone marrow transplant with cells resistant to the virus, although this strategy is not viable for large numbers of infected people. Several clinical trials are underway in which drugs are being used to activate cells that harbour latent HIV. In a recent study, investigators showed that activation of latent HIV infection in patients on antiretroviral therapy could be achieved with a single dose of vorinostat, a licensed anticancer drug that inhibits histone deacetylase. Altho..

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Funding Acknowledgements

SRL has received honoraria and speaking fees from Gilead, Merck, and ViiV Healthcare. She is a principal investigator of investigator-initiated studies sponsored by Gilead, Merck, and Janssen. SE receives research grant support from Abbott, Merck, Pfizer, and ViiV Healthcare. ADK has received an investigator grant for work on a clinical trial and payment for attendance at an international conference from Merck. All other authors declare that they have no conflicts of interest.