Innate cellular responses to rotavirus infection
Gavan Holloway, Barbara S Coulson
JOURNAL OF GENERAL VIROLOGY | MICROBIOLOGY SOC | Published : 2013
Rotavirus is a leading cause of severe dehydrating diarrhoea in infants and young children. Following rotavirus infection in the intestine an innate immune response is rapidly triggered. This response leads to the induction of type I and type III interferons (IFNs) and other cytokines, resulting in a reduction in viral replication. Here we review the current literature describing the detection of rotavirus infection by pattern recognition receptors within host cells, the subsequent molecular mechanisms leading to IFN and cytokine production, and the processes leading to reduced rotavirus replication and the development of protective immunity. Rotavirus countermeasures against innate response..View full abstract
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Awarded by National Health and Medical Research Council of Australia
We are grateful to Jessica Pane and Izabel Di Fiore for critical reading of the manuscript. This work was supported by the National Health and Medical Research Council of Australia (project grant 1023786). B.S.C. is a Senior Research Fellow of the National Health and Medical Research Council.