Journal article

Genetics of febrile seizure subtypes and syndromes: A twin study

Jazmin Eckhaus, Kate M Lawrence, Ingo Helbig, Minh Bui, Lata Vadlamudi, John L Hopper, Ingrid E Scheffer, Samuel F Berkovic



PURPOSE: Febrile seizures (FS) are the most common seizure syndrome. A strong genetic component has been well established through family and twin studies; however, such studies have not examined the genetics of different FS types (simple, complex, febrile status epilepticus) and sub-syndromes (true FS, febrile seizures plus (FS+), 'FS with later epilepsy'). Here we used a community-based twin sample to analyze genetic factors within different FS subtypes and FS syndromes. METHODS: Twin pairs were ascertained from the twin database of the Epilepsy Research Centre. A retrospective chart review was conducted and follow-up attempted for all subjects. Casewise concordance values were calculated f..

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Awarded by National Health & Medical Research Council

Funding Acknowledgements

This research was facilitated through access to the Australian Twin Registry, a national resource supported by an Enabling Grant (ID 628911) from the National Health & Medical Research Council. The study was supported by funding from the National Health and Medical Research Council of Australia. We thank the twins and their families for participating in our research.