Journal article
MyD88 Is a Critical Regulator of Hematopoietic Cell-Mediated Neuroprotection Seen after Stroke
CE Downes, CHY Wong, KJ Henley, PL Guio-Aguilar, M Zhang, R Ates, A Mansell, BT Kile, PJ Crack
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Neuroinflammation is critical in the neural cell death seen in stroke. It has been shown that CNS and peripheral responses drive this neuroinflammatory response in the brain. The Toll-like receptors (TLRs) are important regulators of inflammation in response to both exogenous and endogenous stressors. Taking advantage of a downstream adapter molecule that controls the majority of TLR signalling, this study investigated the role of the TLR adaptor protein myeloid differentiation factor 88 (MyD88) in the control of CNS and peripheral inflammation. Reversible middle-cerebral artery occlusion was used as the model of stroke in vivo; in vitro primary cultured neurons and glia were subject to four..
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Funding Acknowledgements
JC is supported by the National Health and Medical Research Council (NHMRC) of Australia, the National Heart Foundation of Australia and is a holder of an Australian Research Council (ARC) Future Fellowship. AM is supported by the NHMRC. BTK is supported by the NHMRC and the Sylvia and Charles Viertel Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.