Seven new loci associated with age-related macular degeneration

LG Fritsche; W Chen; M Schu; BL Yaspan; Y Yu; G Thorleifsson; DJ Zack; S Arakawa; V Cipriani; S Ripke; RP Igo; GHS Buitendijk; X Sim; DE Weeks; RH Guymer; JE Merriam; PJ Francis; G Hannum; A Agarwal; AM Armbrecht; I Audo; T Aung; GR Barile; M Benchaboune; AC Bird; PN Bishop; KE Branham; M Brooks; AJ Brucker; WH Cade; MS Cain; PA Campochiaro; CC Chan; CY Cheng; EY Chew; KA Chin; I Chowers; DG Clayton; R Cojocaru; YP Conley; BK Cornes; MJ Daly; B Dhillon; AO Edwards; E Evangelou; J Fagerness; HA Ferreyra; JS Friedman; A Geirsdottir; RJ George; C Gieger; N Gupta; SA Hagstrom; SP Harding; C Haritoglou; JR Heckenlively; FG Holz; G Hughes; JPA Ioannidis; T Ishibashi; P Joseph; G Jun; Y Kamatani; N Katsanis; C N Keilhauer; JC Khan; IK Kim; Y Kiyohara; BEK Klein; R Klein; JL Kovach; I Kozak; CJ Lee; KE Lee; P Lichtner; AJ Lotery; T Meitinger; P Mitchell; S Mohand-Saïd; AT Moore; DJ Morgan; MA Morrison; CE Myers; AC Naj; Y Nakamura; Y Okada; A Orlin; MC Ortube; MI Othman; C Pappas; KH Park; GJT Pauer; NS Peachey; O Poch; RR Priya; R Reynolds; AJ Richardson; R Ripp; G Rudolph; E Ryu

Journal article

Seven new loci associated with age-related macular degeneration

LG Fritsche, W Chen, M Schu, BL Yaspan, Y Yu, G Thorleifsson, DJ Zack, S Arakawa, V Cipriani, S Ripke, RP Igo, GHS Buitendijk, X Sim, DE Weeks, RH Guymer, JE Merriam, PJ Francis, G Hannum, A Agarwal, AM Armbrecht Show all

Nature Genetics | NATURE PORTFOLIO | Published : 2013

DOI: 10.1038/ng.2578

Open access

Abstract

Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry. We identified 19 loci associated at P < 5 × 10 -8. These loci show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis. Our results include seven loci with associations reaching P < 5 × 10-8 for the first time, near the genes COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9 and B3GA..

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