Journal article

Alteration of the Thymic T Cell Repertoire by Rotavirus Infection Is Associated with Delayed Type 1 Diabetes Development in Non-Obese Diabetic Mice

Nicole L Webster, Christel Zufferey, Jessica A Pane, Barbara S Coulson



Rotaviruses are implicated as a viral trigger for the acceleration of type 1 diabetes in children. Infection of adult non-obese diabetic (NOD) mice with rotavirus strain RRV accelerates diabetes development, whereas RRV infection in infant NOD mice delays diabetes onset. In this study of infant mice, RRV titers and lymphocyte populations in the intestine, mesenteric lymph nodes (MLN) and thymus of NOD mice were compared with those in diabetes-resistant BALB/c and C57BL/6 mice. Enhanced intestinal RRV infection occurred in NOD mice compared with the other mouse strains. This was associated with increases in the frequency of CD8αβ TCRαβ intraepithelial lymphocytes, and their PD-L1 expression. ..

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Awarded by Juvenile Diabetes Research Foundation

Awarded by National Health and Medical Research Council of Australia

Awarded by University of Melbourne

Awarded by Swiss National Science Foundation

Funding Acknowledgements

This research was supported by the Juvenile Diabetes Research Foundation Award 27-2011-281 (B.S.C.), together with Project Grant 509008 and Senior Research Fellowships 350253 and 628319 (B.S.C.) from the National Health and Medical Research Council of Australia. N.W. was supported by Early Career Researcher Grant 600667 from The University of Melbourne and C.Z. received a Fellowship for Prospective Researchers from the Swiss National Science Foundation (#PBBEP3 128392). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.