Journal article

Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2

Naghmeh Varghayee, Michael A Krezel, Linda Rezmann, Laurie Chow, Albert George Frauman, William J Louis, Simon N Louis

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | SAGE PUBLICATIONS LTD | Published : 2015

Abstract

HYPOTHESIS: Cardiac hypertrophy in myocytes is in part regulated by changes in expression of a novel Ang II type 2 receptor (AT2-receptor) interacting protein identified as ATIP. INTRODUCTION: The role of the AT2-receptor in cardiac hypertrophy is controversial, with some reports indicating that AT2-receptor activation has detrimental effects on disease progression, whereas others indicate that it has a beneficial role. MATERIALS AND METHODS: In an effort to unravel this paradox, we examined the expression and function of ATIP in cell-based models of cardiac hypertrophy using QPCR, immunohistochemistry, cell proliferation, morphological and transfection techniques in H9c2 cardio-myoblast and..

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