Journal article

Transplanted progenitors generate functional enteric neurons in the postnatal colon

Ryo Hotta, Lincon A Stamp, Jaime PP Foong, Sophie N McConnell, Annette J Bergner, Richard B Anderson, Hideki Enomoto, Donald F Newgreen, Florian Obermayr, John B Furness, Heather M Young

JOURNAL OF CLINICAL INVESTIGATION | AMER SOC CLINICAL INVESTIGATION INC | Published : 2013

Abstract

Cell therapy has the potential to treat gastrointestinal motility disorders caused by diseases of the enteric nervous system. Many studies have demonstrated that various stem/progenitor cells can give rise to functional neurons in the embryonic gut; however, it is not yet known whether transplanted neural progenitor cells can migrate, proliferate, and generate functional neurons in the postnatal bowel in vivo. We transplanted neurospheres generated from fetal and postnatal intestinal neural crest-derived cells into the colon of postnatal mice. The neurosphere-derived cells migrated, proliferated, and generated neurons and glial cells that formed ganglion-like clusters within the recipient co..

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Grants

Awarded by NHMRC project


Awarded by ARC Discovery


Awarded by Research Fellowship from the German Research Foundation (DFG)


Awarded by Grants-in-Aid for Scientific Research


Funding Acknowledgements

We thank Louise Pontell, Michelle Thacker, Adam Wallace, and DongCheng Zhang for excellent technical assistance and Joel Bornstein for use of equipment. This work was supported by NHMRC project grants 546473 and 1019931 and by ARC Discovery grant DP0878755. F. Obermayr is supported by a Research Fellowship from the German Research Foundation (DFG; OB 381/1-1).