Journal article

Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels

Adam J Walker, Sandy A Burnett, Kyoko Hasebe, Jane A McGillivray, Laura J Gray, Sean L McGee, Ken Walder, Michael Berk, Susannah J Tye



Several animal models are currently utilised in the investigation of major depressive disorder; however, each is validated by its response to antidepressant pharmacotherapy. Few animal models consider the notion of antidepressant treatment resistance. Chronic daily administration of adrenocorticotropic hormone (ACTH) or corticosterone can alter behavioural responses to antidepressants, effectively blocking antidepressant efficacy. Herein, we demonstrate that ACTH-(1-24) (100μg/day; 14 days) blocks the immobility-reducing 'antidepressant' effects of a single dose of imipramine (10mg/kg) in the forced swim test. This finding was accompanied by altered monoamine tissue levels in the prefrontal ..

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University of Melbourne Researchers


Funding Acknowledgements

This research was supported by a NARSAD Young Investigator Award to SJT. SLM is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC) of Australia. AJW is supported by an Australian Postgraduate Award.