New White Matter Brain Injury After Infant Heart Surgery Is Associated With Diagnostic Group and the Use of Circulatory Arrest
John Beca, Julia K Gunn, Lee Coleman, Ayton Hope, Peter W Reed, Rodney W Hunt, Kirsten Finucane, Christian Brizard, Brieana Dance, Lara S Shekerdemian
CIRCULATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013
BACKGROUND: Abnormalities on magnetic resonance imaging scans are common both before and after surgery for congenital heart disease in early infancy. The aim of this study was to prospectively investigate the nature, timing, and consequences of brain injury on magnetic resonance imaging in a cohort of young infants undergoing surgery for congenital heart disease both with and without cardiopulmonary bypass. METHODS AND RESULTS: A total of 153 infants undergoing surgery for congenital heart disease at <8 weeks of age underwent serial magnetic resonance imaging scans before and after surgery and at 3 months of age, as well as neurodevelopmental assessment at 2 years of age. White matter injury..View full abstract
The Hearts and Minds Study received funding support from the Heart Foundation of New Zealand, National Heart Foundation of Australia, Auckland Medical Research Fund, Green Lane Research and Education Fund, Australian and New Zealand Intensive Care Foundation, Murdoch Children's Research Institute, and Victorian Government's Operational Infrastructure Support Program.