Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia

CL Whitehead; SP Walker; M Lappas; S Tong

Journal article

Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia

CL Whitehead, SP Walker, M Lappas, S Tong

JOURNAL OF PERINATOLOGY | NATURE PUBLISHING GROUP | Published : 2013

DOI: 10.1038/jp.2013.16

Abstract

OBJECTIVE: To determine whether the intrinsic apoptosis pathway is differentially expressed in placenta and maternal blood in severe preterm fetal growth restriction (FGR) and pre-eclampsia (PE), and to examine whether circulating RNA in maternal blood may be potential biomarkers. STUDY DESIGN: Maternal blood samples and placental biopsies were collected from women with preterm: FGR (n=20), PE without FGR (n=8) and controls (n=20). Real-time PCR examined the expression of genes in the intrinsic apoptosis pathway in FGR and PE, stratified according to the severity of placental insufficiency. RESULT: Severe preterm FGR, with or without PE, was associated with increased expression of BCL2, BCL-..

View full abstract

University of Melbourne Researchers

Susan Walker Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Stephen Tong Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Clare Whitehead Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Martha Lappas Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Related Projects (3)

R. DOUGLAS WRIGHT BIOMEDICAL CAREER DEVELOPMENT AWARD - (UNDERSTANDING THE MECHANISMS THAT REGULATE THE ONSET OF HUMAN LABOUR AND DELIVERY)

nan

CAREER DEVELOPMENT AWARD - CLINICAL

Recent evidence has pointed to the beginning of pregnancy as the time when biological cascades begin that cause common diseases of pregnancy..

MEASURING RNA IN MATERNAL BLOOD TO MONITOR THE WELLBEING OF GROWTH-RESTRICTED FETUSES

Severely growth restricted fetuses are at peril of stillbirth from low oxygenation. While ultrasound monitoring improves outcomes, babies ar..

Grants

Awarded by NHMRC Project Grant

Awarded by NHMRC Career Development Fellowships

Funding Acknowledgements

We are grateful for funding from the Royal Australian and New Zealand College of Obstetricians and Gynecologists Arthur Wilson Scholarship, a William Buckland Foundation Grant, a Medical Research Foundation For Women and Babies Grant and a NHMRC Project Grant (no.1028521). ML and ST are supported by NHMRC Career Development Fellowships (MLno.454777) (STno.490870). We thank Gillian Barker for her assistance in sample processing. This project was funded by a Royal Australian and New Zealand College of Obstetricians and Gynecologists Arthur Wilson Scholarship, a William Buckland Foundation Grant, a Medical Research Foundation For Women and Babies Grant and a NHMRC Project Grant (no.1028521). ML and ST are supported by NHMRC Career Development Fellowships (STno.490970)