Journal article

Obesity and the Microvasculature: A Systematic Review and Meta-Analysis

Adrien Boillot, Sophia Zoungas, Paul Mitchell, Ronald Klein, Barbara Klein, Mohammad Kamran Ikram, Caroline Klaver, Jie Jin Wang, Bamini Gopinath, E Shyong Tai, Aljoscha Steffen Neubauer, Serge Hercberg, Laima Brazionis, Seang-Mei Saw, Tien-Yin Wong, Sebastien Czernichow



BACKGROUND: Overweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber. METHODS AND FINDINGS: Relevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

Funding was provided by the National Health and Medical Research Council (#124317, #396414, #209057), the National Heart Foundation, and the Centre for Clinical Research Excellence in Clinical Science in Diabetes. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.