Behavioural and Anatomical Characterization of Mutant Mice With Targeted Deletion of D-1 Dopamine Receptor-Expressing Cells: Response to Acute Morphine
Daniela Babovic, Luning Jiang, Satoshi Goto, Ilse Gantois, Guenter Schuetz, Andrew J Lawrence, John L Waddington, John Drago
JOURNAL OF PHARMACOLOGICAL SCIENCES | JAPANESE PHARMACOLOGICAL SOC | Published : 2013
Considerable topographic overlap exists between brain opioidergic and dopaminergic neurons. Pharmacological blockade of the dopamine D(1) receptor (Drd1a) reverses several behavioural phenomena elicited by opioids. The present study examines the effects of morphine in adult mutant (MUT) mice expressing the attenuated diphtheria toxin-176 gene in Drd1a-expressing cells, a mutant line shown previously to undergo post-natal striatal atrophy and loss of Drd1a-expression. MUT and wild-type mice were assessed behaviourally following acute administration of 10 mg/kg morphine. Treatment with morphine reduced locomotion and rearing similarly in both genotypes but reduced total grooming only in MUT mi..View full abstract
Awarded by Science Foundation Ireland
Funding for the present study was provided by the Australian National Health & Medical Research Council, the Victorian Government's Operational Infrastructure Support Program, and Science Foundation Ireland Principal Investigator grant 07/IN.1/B960. JD & AJL are NHMRC Research Fellows. The funding agencies played no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. We thank Jim Massalas for technical assistance.