Journal article
Intensive therapy following upper limb botulinum toxin A injection in young children with unilateral cerebral palsy: A randomized trial
B Hoare, C Imms, E Villanueva, HB Rawicki, T Matyas, L Carey
Developmental Medicine and Child Neurology | Published : 2013
DOI: 10.1111/dmcn.12054
Abstract
AIM Botulinum toxin A (BoNT-A) combined with occupational therapy is effective in improving upper limb outcomes in children with unilateral cerebral palsy (CP). It is now essential to identify the most effective therapies following BoNT-A. Given the added burden for children and families, the aim of this study was to explore whether modified constraintinduced movement therapy (mCIMT) leads to sufficiently superior gains compared with bimanual occupational therapy (BOT) in young children with unilateral CP following BoNT-A injections. METHOD In this randomized, controlled, evaluator-blinded trial, 34 children (20 males, 14 females; mean age 3y, SD 1y 4mo, range 18mo-6y) with unilateral CP wer..
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Funding Acknowledgements
The authors wish to express their sincere gratitude to the children and their families who participated in this trial. They also sincerely thank Trisnawati Tanumihardjo, Melanie Toy-Laing, and Cate Clancy for administering the assessments and Lena Krumlinde-Sundholm, Marie Holmefur, and Sue Greaves for scoring all the videos. We also thank Natasha Lannin for her assistance and ongoing support with statistics. Finally, the authors acknowledge Allergan Australia, Southern Health, and La Trobe University for supporting this research. The study was funded by grants from La Trobe University, Southern Health, and Allergan Australia Pty Ltd. Allergan Australia provided partial support by providing the BoNT-A (Botox) used in the study, by payment of research assistants for blinded administration and scoring of assessments, and video-editing services. The authors have no pecuniary interest in Allergan. BH is an occupational therapist and has received sponsorship from Allergan Australia to attend and teach at conferences and meetings but has no personal financial interest in Botox or any related product. CI is co-investigator of an RCT investigating the effect of repeat injections of BoNT-A and occupational therapy in the upper limbs of children with unilateral CP that has received support from Allergan Australia. In 2008, CI received a grant from Allergan Australia to present results of this trial at the American Academy of Cerebral Palsy and Developmental Medicine in Atlanta, but has no personal financial interest in Botox or any related product. HBR has received sponsorship from Allergan Australia to attend and teach at conferences and meetings but has no personal financial interest in Botox or any related product.