Journal article
[(η6-praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity
M Patra, K Ingram, V Pierroz, S Ferrari, B Spingler, RB Gasser, J Keiser, G Gasser
Chemistry A European Journal | Published : 2013
Abstract
The antischistosomal effect of two [(η6-praziquantel)Cr(CO) 3] derivatives was investigated. The compounds (see figure: Cr purple, N blue, O red) were prepared in a one-step procedure from commercially available praziquantel. Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and only a minor cytotoxic effect on selected mammalian cell lines. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Grants
Awarded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Funding Acknowledgements
This work was financially supported by the Swiss National Science Foundation (SNSF Professorships PP00P2 133568 to G.G. and PP00P3 135170 to J.K.), the Scientific & Technological Cooperation Programme Switzerland-Russia (J.K. and K.I.), the University of Zurich (G.G. and S.F.). S.F. acknowledges the Stiftung fur Wissenschaftliche Forschung of the University of Zurich, the Stiftung zur Krebsbekampfung, the Huggenberger-Bischoff Stiftung, and the University of Zurich Priority Program. R.B.G. acknowledges the Australian Research Council, the National Health and Medical Research Council, and the Melbourne Water Corporation. We are grateful to Dr. Henrik Braband for X-ray data collection.