Skeletal Muscle Insulin Resistance Associated with Cholesterol-Induced Activation of Macrophages Is Prevented by High Density Lipoprotein
Andrew L Carey, Andrew L Siebel, Medini Reddy-Luthmoodoo, Alaina K Natoli, Wilissa D'Souza, Peter J Meikle, Dmitri Sviridov, Brian G Drew, Bronwyn A Kingwell
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2013
Emerging evidence suggests that high density lipoprotein (HDL) may modulate glucose metabolism through multiple mechanisms including pancreatic insulin secretion as well as insulin-independent glucose uptake into muscle. We hypothesized that HDL may also increase skeletal muscle insulin sensitivity via cholesterol removal and anti-inflammatory actions in macrophages associated with excess adiposity and ectopic lipid deposition.
This study was supported by the National Health and Medical Research Council of Australia and the Operational Infrastructure Support (OIS) Scheme of the Victorian State Government. BAK and DS are fellows of the National Health and Medical Research Council. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.