Journal article
Induction of SerpinB2 and Th1/Th2 Modulation by SerpinB2 during Lentiviral Infections In Vivo
Lee D Major, Thomas S Partridge, Joy Gardner, Stephen J Kent, Robert de Rose, Andreas Suhrbier, Wayne A Schroder
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
SerpinB2, also known as plasminogen activator inhibitor type 2, is a major product of activated monocytes/macrophages and is often strongly induced during infection and inflammation; however, its physiological function remains somewhat elusive. Herein we show that SerpinB2 is induced in peripheral blood mononuclear cells following infection of pigtail macaques with CCR5-utilizing (macrophage-tropic) SIVmac239, but not the rapidly pathogenic CXCR4-utilizing (T cell-tropic) SHIVmn229. To investigate the role of SerpinB2 in lentiviral infections, SerpinB2(-/-) mice were infected with EcoHIV, a chimeric HIV in which HIV gp120 has been replaced with gp80 from ecotropic murine leukemia virus. EcoH..
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Funding Acknowledgements
Funding was provided by the Australian National Health and Medical Research Council (NH&MRC) and the Australian Centre for HIV and Hepatitis Virology Research. TSP received a QIMR honours scholarship for this work. AS is a Principle Research Fellow with the NH&MRC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.