Journal article
Induction of SerpinB2 and Th1/Th2 Modulation by SerpinB2 during Lentiviral Infections In Vivo
LD Major, TS Partridge, J Gardner, SJ Kent, R de Rose, A Suhrbier, WA Schroder
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
SerpinB2, also known as plasminogen activator inhibitor type 2, is a major product of activated monocytes/macrophages and is often strongly induced during infection and inflammation; however, its physiological function remains somewhat elusive. Herein we show that SerpinB2 is induced in peripheral blood mononuclear cells following infection of pigtail macaques with CCR5-utilizing (macrophage-tropic) SIVmac239, but not the rapidly pathogenic CXCR4-utilizing (T cell-tropic) SHIVmn229. To investigate the role of SerpinB2 in lentiviral infections, SerpinB2-/- mice were infected with EcoHIV, a chimeric HIV in which HIV gp120 has been replaced with gp80 from ecotropic murine leukemia virus. EcoHIV..
View full abstractGrants
Funding Acknowledgements
Funding was provided by the Australian National Health and Medical Research Council (NH&MRC) and the Australian Centre for HIV and Hepatitis Virology Research. TSP received a QIMR honours scholarship for this work. AS is a Principle Research Fellow with the NH&MRC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.