Journal article

Signalling by the beta c family of cytokines

Timothy R Hercus, Urmi Dhagat, Winnie LT Kan, Sophie E Broughton, Tracy L Nero, Michelle Perugini, Jarrod J Sandow, Richard J D'Andrea, Paul G Ekert, Timothy Hughes, Michael W Parker, Angel F Lopez



The GM-CSF, IL-3 and IL-5 family of cytokines, also known as the βc family due to their receptors sharing the signalling subunit βc, regulates multiple biological processes such as native and adaptive immunity, inflammation, normal and malignant hemopoieis, and autoimmunity. Australian scientists played a major role in the discovery and biological characterisation of the βc cytokines and their recent work is revealing unique features of cytokine receptor assembly and signalling. Furthermore, specific antibodies have been generated to modulate their function. Characterisation of the structural and dynamic requirements for the activation of the βc receptor family and the molecular definition o..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

This work was supported by a National Health and Medical Research Council of Australia (NHMRC) Program Grant (565217) to A.F.L. and M.W.P. and NHMRC Project Grants (395512, 559001) to T.R.H., M.W.P. and A.F.L. This work was also supported by Cancer Australia and the Victorian Cancer Council. This work was partly carried out in the Australian Cancer Research Foundation Rational Drug Discovery Centre. Infrastructure support from the NHMRC Independent Research Institutes Infrastructure Support Scheme and the Victorian State Government Operational Infrastructure Support Program to St. Vincent's Institute are gratefully acknowledged. T.H. is an NHMRC Practitioner Fellow. M.W.P. is an NHMRC Fellow (448300). T.R.H., S.E.B., U.D., T.H., A.F.L. and M.W.P. collaborate with the biopharmaceutical company CSL Ltd on therapeutic applications on some of the work presented here.