Epigenetic changes in diabetes
ST Keating, A El-Osta
CLINICAL GENETICS | WILEY | Published : 2013
Diabetes is a multifactorial disease with numerous pathways influencing its progression and recent observations suggest that the complexity of the disease cannot be entirely accounted for by genetic predisposition. A compelling argument for an epigenetic component is rapidly emerging. Epigenetic processes at the chromatin template significantly sensitize transcriptional and phenotypic outcomes to environmental signaling information including metabolic state, nutritional requirements and history. Epigenetic mechanisms impact gene expression that could predispose individuals to the diabetic phenotype during intrauterine and early postnatal development, as well as throughout adult life. Further..View full abstract
The authors acknowledge grant, scholarship and fellowship support from the Juvenile Diabetes Research Foundation International (JDRF), the Diabetes Australia Research Trust (DART), the National Health and Medical Research Council (NHMRC), Australian Postgraduate Award (APA) and the National Heart Foundation of Australia (NHF). A.E-O. is a Senior Research Fellow supported by the NHMRC. This article was supported in part by the Victorian Government's Operational Infrastructure Support Program.