The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation
Smriti Murali Krishna, Anthony Dear, Jeffrey M Craig, Paul E Norman, Jonathan Golledge
ATHEROSCLEROSIS | ELSEVIER IRELAND LTD | Published : 2013
Previous studies have suggested that homocysteine (Hcy) has wide-ranging biological effects, including accelerating atherosclerosis, impairing post injury endothelial repair and function, deregulating lipid metabolism and inducing thrombosis. However, the biochemical basis by which hyperhomocysteinemia (HHcy) contributes to cardiovascular diseases (CVDs) remains largely unknown. Several case-control studies have reported an association between HHcy and the presence of abdominal aortic aneurysms (AAA) and there are supportive data from animal models. Genotypic data concerning the association between variants of genes involved in the methionine cycle and AAA are conflicting probably due to pro..View full abstract
Awarded by National Health and Medical Research Council
Awarded by National Health and Medical Research Council, Australia
This work is funded by grants from the National Health and Medical Research Council (540404, 1021416) and the BUPA Foundation. JG holds a Practitioner Fellowship from the National Health and Medical Research Council, Australia (1019921) and a Senior Clinical Research Fellowship from the Queensland Government. The authors wish to thank Faculty of Medicine and Health Sciences, James Cook University for a FIAG grant.