Journal article
Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study
DJ Mcmillan, PA Drèze, T Vu, DE Bessen, J Guglielmini, AC Steer, JR Carapetis, L Van Melderen, KS Sriprakash, PR Smeesters, Michael Batzloff, R Towers, H Goossens, S Malhotra-Kumar, L Guilherme, RosangelaTorres, D Low, A Mc Geer, P Krizova, S El Tayeb Show all
Clinical Microbiology and Infection | WILEY-BLACKWELL | Published : 2013
Abstract
Group A Streptococcus (GAS) M protein is an important virulence factor and potential vaccine antigen, and constitutes the basis for strain typing (emm-typing). Although >200 emm-types are characterized, structural data were obtained from only a limited number of emm-types. We aim to evaluate the sequence diversity of near-full-length M proteins from worldwide sources and analyse their structure, sequence conservation and classification. GAS isolates recovered from throughout the world during the last two decades underwent emm-typing and complete emm gene sequencing. Predicted amino acid sequence analyses, secondary structure predictions and vaccine epitope mapping were performed using MUSCLE..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the European Society for Clinical Microbiology and Infectious Diseases, European Society for Paediatric Infectious Diseases, Fonds National de la Recherche Scientifique (Belgium), Fonds Brachet and Fondation Van Buuren (Belgium), Australian National Health and Medical Research Council, National Institutes of Health (AI-065572). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.