Journal article
Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4
RCW Ma, C Hu, CH Tam, R Zhang, P Kwan, TF Leung, GN Thomas, MJ Go, K Hara, X Sim, JSK Ho, C Wang, H Li, L Lu, Y Wang, JW Li, Y Wang, VKL Lam, J Wang, W Yu Show all
Diabetologia | SPRINGER | Published : 2013
Abstract
Aims/hypothesis: Most genetic variants identified for type 2 diabetes have been discovered in European populations. We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel variants for type 2 diabetes in Asians. Methods: We performed a meta-analysis of three GWAS comprising 684 patients with type 2 diabetes and 955 controls of Southern Han Chinese descent. We followed up the top signals in two independent Southern Han Chinese cohorts (totalling 10,383 cases and 6,974 controls), and performed in silico replication in multiple populations. Results: We identified CDKN2A/B and four novel type 2 diabetes association signals with p < 1 × 10-5 f..
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Awarded by National Research Foundation of Korea
Funding Acknowledgements
This Hong Kong arm of the project was supported by the Hong Kong Foundation for Research and Development in Diabetes established under the auspices of the Chinese University of Hong Kong, the Hong Kong Governments Research Grant Committee Central Allocation Scheme (CUHK 1/04C), a Research Grants Council Earmarked Research Grant (CUHK4724/07M), the Innovation and Technology Fund (ITS/088/08 and ITS/487/09FP), National Institutes of Health Grant NIH-RFA DK-085545-01 (from the National Institute of Diabetes and Digestive and Kidney Diseases), a Chinese University Focused Investment Fund, a Chinese University Direct Grant, and support from the Research Fund of the Department of Medicine and Therapeutics and the Diabetes and Endocrine Research Fund of the Chinese University of Hong Kong. T. F. Leung. is supported by the Research Grants Council General Research Fund (469908 and 470909) and the CUHK Research Committee Group Research Scheme (3110034 and 3110060). P. Kwan and S. S. Cherny are supported by the Research Grants Council of the Hong Kong Special Administrative Region, China (HKU762308M and CUHK4466/06M). N. L. S. Tang. acknowledges support from the Sir Michael and Lady Kadoorie Funded Research Into Cancer Genetics and a CUHK direct grant. J. W. Li. and T. F. Chan. are supported by the RGC General Research Fund (461708). G. N. Thomas acknowledges support from the Research Grants Council Earmarked Research Fund (HKU7672/06M).