Journal article

Suppression of cytokine signaling: The SOCS perspective

Edmond M Linossi, Jeffrey J Babon, Douglas J Hilton, Sandra E Nicholson

CYTOKINE & GROWTH FACTOR REVIEWS | ELSEVIER SCI LTD | Published : 2013

Abstract

The discovery of the Suppressor of Cytokine Signaling (SOCS) family of proteins has resulted in a significant body of research dedicated to dissecting their biological functions and the molecular mechanisms by which they achieve potent and specific inhibition of cytokine and growth factor signaling. The Australian contribution to this field has been substantial, with the initial discovery of SOCS1 by Hilton, Starr and colleagues (discovered concurrently by two other groups) and the following work, providing a new perspective on the regulation of JAK/STAT signaling. In this review, we reflect on the critical discoveries that have lead to our current understanding of how SOCS proteins function..

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Grants

Awarded by National Health and Medical Research Council (NHMRC), Australia


Awarded by NHMRC IRIISS


Awarded by ARC


Awarded by National Institutes of Health


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

We thank Warren Alexander and Nick Nicola for critical reading of this manuscript. This work was supported in part by the National Health and Medical Research Council (NHMRC), Australia (Program Grant #487922), as well as an NHMRC IRIISS Grant 361646 and a Victorian State Government Operational Infrastructure Scheme grant. S.E.N. is supported by an NHMRC Fellowship, J.J.B. by an ARC Future Fellowship (FT110100169) and E.M.L. by an Australian Postgraduate Award. This work was also supported in part by the National Institutes of Health (RO1 CA-22556).