Absence epilepsy subnetworks revealed by event-related independent components analysis of functional magnetic resonance imaging
Richard AJ Masterton, Patrick W Carney, David F Abbott, Graeme D Jackson
EPILEPSIA | WILEY | Published : 2013
PURPOSE: The aim of this study was to provide better spatiotemporal description of the brain activity observed during generalized spike-and-wave (GSW) discharges. Simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI) studies of these epileptiform events have shown regional differences in the timing of fMRI signal changes, which suggests activities within multiple interacting networks rather than a single unified network. METHODS: EEG-fMRI recordings from eight patients with childhood absence epilepsy (CAE) were studied using event-related independent components analysis (eICA). This technique separates the fMRI signal changes observed during GSW discharges ..View full abstract
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Awarded by National Health and Medical Research Council of Australia
We thank the patients and their families for participation in this work; Dr. A. Simon Harvey, Professor Ingrid Scheffer, and the Royal Children's Hospital, Melbourne, for assistance in patient recruitment; and Danny Flanagan for assistance with EEG recording, reporting, and analysis. Funding was received from Pfizer Inc (Neuroscience Research Grant), the Dowd Foundation, the National Health and Medical Research Council of Australia (Program Grant 628952 and practitioner fellowship 527800 to GDJ), and the Operational Infrastructure Support Program of the State Government of Victoria, Australia.