Journal article
Relationship between breast milk sCD14, TGF-β1 and total IgA in the first month and development of eczema during infancy
IH Ismail, PV Licciardi, F Oppedisano, RJ Boyle, MLK Tang
Pediatric Allergy and Immunology | WILEY-BLACKWELL | Published : 2013
DOI: 10.1111/pai.12075
Abstract
Introduction: The overall beneficial effects of breastfeeding for infants have been well documented, but its role in allergy prevention is controversial. Objective: We investigated the relationship between breast milk immunomodulatory factors and subsequent development of eczema and atopic sensitization in the first year of life. Methods: Day 7 and 28 breast milk samples were collected from mothers carrying infants at high risk of allergic disease. Aqueous-phase breast milk samples were assayed for TGF-β1, sCD14 and total IgA. Infants were assessed for the presence of eczema and atopic sensitization at 12 months of age. The levels of breast milk TGF-β1, sCD14 and total IgA were compared in i..
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Funding Acknowledgements
The studies were funded by grants from the Jack Brockhoff Foundation, the Murdoch Children's Research Institute (MCRI) and the Ilhan Food Allergy Foundation. Intan Hakimah Ismail was supported by a scholarship from the Ministry of Higher Education, Malaysia and Universiti Putra Malaysia. Robert Boyle was supported by a University of Melbourne Baillieu Scholarship, a Murdoch Children's Research Institute Postgraduate Scholarship and a National Institute for Health Research Comprehensive Biomedical Research Centre. LGG and placebo capsules were manufactured and supplied by Dicofarm ltd (Roma, Italy). The MCRI receives infrastructure funding from the Victorian Government's Operational Infrastructure Support Program.