Journal article
Dysregulation of the basal RNA polymerase transcription apparatus in cancer
MJ Bywater, RB Pearson, GA McArthur, RD Hannan
Nature Reviews Cancer | Published : 2013
DOI: 10.1038/nrc3496
Abstract
Mutations that directly affect transcription by RNA polymerases rank among the most central mediators of malignant transformation, but the frequency of new anticancer drugs that selectively target defective transcription apparatus entering the clinic has been limited. This is because targeting the large protein-protein and protein-DNA interfaces that control both generic and selective aspects of RNA polymerase transcription has proved extremely difficult. However, recent technological advances have led to a 'quantum leap' in our comprehension of the structure and function of the core RNA polymerase components, how they are dysregulated in a broad range of cancers and how they may be targeted..
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Funding Acknowledgements
Owing to scope and space limitations the authors have not been able to individually cite many of the original publications that have contributed substantially to the field. The authors sincerely apologize to the authors of these publications. This work was supported by the National Health and Medical Research Council (NHMRC) of Australia programme and project grants; Leukemia Foundation Grant in Aid; Prostate Cancer Foundation of Australia grant in aid; NHMRC Research Fellowship to R.D.H. and R.B.P.; NHMRC Postgraduate Research Scholarship, GSK Postgraduate Research Scholarship and Leukemia Foundation Postdoctoral Fellowship to M.J.B.; Cancer Council of Victoria Sir Edward Weary Dunlop Clinical Research Fellowship and NHMRC Clinical Research Fellowship to G.A.M.