Immunogenicity and Immunomodulatory Properties of Hepatocyte-like Cells Derived from Human Amniotic Epithelial Cells
Jing Yang Tee, Vijesh Vaghjiani, Yu Han Liu, Padma Murthi, James Chan, Ursula Manuelpillai
CURRENT STEM CELL RESEARCH & THERAPY | BENTHAM SCIENCE PUBL LTD | Published : 2013
Hepatocyte transplantation is being trialled as an alternative to whole organ transplant for patients with acute liver failure and liver specific metabolic diseases. Due to the scarcity of human hepatocytes, hepatocyte-like cells (HLC) generated from stem cells may become a viable alternative to hepatocyte transplantation. Human amniotic epithelial cells (hAEC) from the placenta have stem cell-like properties and can be differentiated into HLC. Naïve hAEC have low immunogenicity and exert immunomodulatory effects that may facilitate allogeneic transplantation. However, whether the immunogenicity and immunomodulatory properties alter with differentiation into HLC are unknown. We further chara..View full abstract
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Awarded by Australian National Health & Medical Research Council (NHMRC)
UM supported by grant #606473 from the Australian National Health & Medical Research Council (NH & MRC); PM by #509140 and JC by program grant #436634. Study funded by a grant from Arthur A. Thomas Trust to UM. JYT, VV and UM are supported by the Victorian Government's Operational Infrastructure Support Program.